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Is fluorine-18 fluorodeoxyglucose positron emission tomography useful for detecting bladder lesions? A meta-analysis of the literature
Wang N. Jiang P. Lu Y.
Urologia Internationalis 2014;92(2):143-9.
Objective To evaluate the diagnostic accuracy of fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in the detection of bladder lesions.
Methods We conducted a systematic PubMed/MEDLINE and Embase database search of articles published before November 2012. Sensitivity, specificity, likelihood ratio and diagnostic odds ratio were pooled. A summary receiver operating characteristic curve was also used to summarize overall test performance. All meta-analyses were performed using the Meta-DiSc software (version 1.4).
Results Six studies met the inclusion criteria. The pooled sensitivity and specificity of PET or PET/CT for the detection of bladder cancer was 80.0% (95% CI: 71.0-87.0%) and 84.0% (95% CI: 69.0-93.0%), respectively. The overall positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 3.47 (95% CI: 1.03-11.65), 0.31 (95% CI: 0.13-0.70) and 13.86 (95% CI: 2.84-67.74), respectively. Besides, the area (± standard error) under the symmetrical summary receiver operating characteristic curve was 0.8574 ± 0.0704.
Conclusion When compared with results of MRI and CT published by other studies, (18)F-FDG PET or PET/CT showed no superiority in detecting local bladder lesions. As a whole body imaging, it is suggested that PET is more appropriate for the detection of metastasis.
Copyright © 2013 S. Karger AG, Basel.