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ESMO2014 update on Abiraterone

Abiraterone and prednisone in men with CRPC prior to docetaxel earlier showed improved progression-free survival but follow up was too short to meet the co-primary endpoint of the COU-AA302 study: overall survival.

Now longer follow up data from the COU-AA302 study in mentioned population were presented at ESMO2014 by Dr. Charles Ryan. At 49.2m follow up abiraterone prolonged overall survival with 4.3m to 34.7m. This is an interesting observation since subsequent treatments were frequent and 44% of men in the control arm later received abiraterone.

Early abiraterone and prednisone in men with CRPC provides a significant overall survival benefit despite the frequent need of subsequent treatments.