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Outcome of Patients With Metastatic Sarcomatoid Renal Cell Carcinoma: Results From the International Metastatic Renal Cell Carcinoma Database Consortium
Clinical Genitourinary Cancer, 2015;13:e79 - e85
Sarcomatoid renal cell carcinoma is associated with poor prognosis. Data regarding outcome in the targeted therapy era are lacking.
Patients and Methods
Clinical, prognostic, and treatment parameters in metastatic renal cell carcinoma patients with and without sarcomatoid histology treated with targeted therapy were retrospectively analyzed.
Two thousand two hundred eighty-six patients were identified (sRCC: n = 230 and non-sRCC: n = 2056). sRCC patients had significantly worse IMDC prognostic criteria compared with non-sRCC (11% vs. 19% favorable risk; 49% vs. 57% intermediate risk, and 40% vs. 24% poor risk;P < .0001). Time from original diagnosis to relapse (excluding synchronous metastatic disease) was shorter in the sRCC group (18.8 vs. 42.9 months;P < .0001). There was no significant difference in the incidence of central nervous system metastases (6%-8%) or underlying clear cell histology (87%-88%). More than 93% of patients received VEGF inhibitors as first-line therapy; objective response was less common in sRCC whereas primary refractory disease was more common (21% vs. 26% and 43% vs. 21%;P < .0001, for both). sRCC patients had significantly less use of second- (P = .018) and third-line (P < .0001) systemic therapy. The median progression-free survival (PFS)/overall survival (OS) was 4.5/10.4 months in sRCC patients and 7.8/22.5 months in non-sRCC patients (P < .0001 for both). Sarcomatoid histology was associated with a significantly worse PFS and OS after adjusting for individual IMDC risk factors in multivariable analysis (hazard ratio, 1.5;P < .0001 for both).
Patients with sRCC have a shorter time to relapse, worse baseline prognostic criteria, and worse clinical outcome with targeted therapy. Additional insight into the biology of sRCC is needed to develop alternative therapeutics.
Keywords: IMDC risk model, Kidney cancer, Overall survival, Prognostication, Targeted therapies.
1 Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
2 Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
3 Department of Urology, University Hospital of Greifswald, Greifswald, Germany
4 Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
5 Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA
6 Department of Medicine, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
7 Department of Medical Oncology, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada
8 Department of Medical Oncology, Western University, London, Ontario, Canada
9 Department of Medicine and Urology, Queen Elizabeth II Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada
10 Department of Medical Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI
11 Department of Medical Oncology, University of Utah Huntsman Cancer Institute, Salt Lake City, UT
12 Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA
13 Department of Medical Oncology, National Cancer Centre Singapore, Singapore
14 Department of Internal Medicine, Yonsei Cancer Center, Yonsei University Health System, Institute for Cancer Research, Yonsei University College of Medicine, Seoul, South Korea
15 Departments of Urology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
16 Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
17 Department of Oncology, Cross Cancer Center, University of Alberta, Edmonton, Alberta, Canada
18 Department of Medical Oncology, Tom Baker Cancer Center, University of Calgary, Calgary, Alberta, Canada
∗ Address for correspondence: Christos E. Kyriakopoulos, MD, Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Ave, Desk R35, Cleveland, OH 44195 Fax: 216-636-1937
© 2015 Elsevier Inc., All rights reserved.